Khelma Longevity Multipath Anti-aging Food Supplements enhances health-span by optimizing long term Cellular Health and offers a completely new approach to improve many aspects of health. Khelma Longevity products improve Quality of Life better than other form of supplementation. This Quality of Life improvement is closely related with Cellular Aging. Optimal Cellular Health can maintain youth in young bodies or reverse the ravages of time for those who are in their more mature years.

Customized to Personalized Needs

Depending on individual nutritional needs and personal health focus, the assembly of a customized Khelma Longevity program -by choosing the most appropriate body-system-specific Multipath Anti-Aging formula- is possible for revitalization of needs.


From DNA damage to cellular miscommunication, aging is a mysterious and multifarious process.

Aging is the outcome of diverse and complex changes in normal biological functions, from the accumulation of DNA damage to dysfunction of proteins and altered communication both within cells and among distant tissues in the body.

The Hallmarks of aging

Slowing or reversing the aging process has been a hot topic since the beginning of time. Aging can be defined as a systems-wide decline in organismal function.

Decline occurs as a result of numerous events in the organism and these events can be classified into nine “hallmarks” of aging:

  • Genomic Instability,
  • Telomere Attrition,
  • Epigenetic Alterations,
  • Loss of Proteostasis,
  • Deregulated Nutrient-sensing,
  • Mitochondrial Dysfunction,
  • Cellular Senescence,
  • Stem Cell Exhaustion,
  • Altered Intercellular Communication

Aging hallmarks can be divided into three categories: (1) primary, or the causes of age-associated damage; (2) antagonistic, or the responses to the damage; and (3) integrative, or the consequences of the responses and culprits of the aging phenotype.

By understanding the hallmarks in greater detail, we can get closer to developing intervention strategies that can make the aging process less of a decline, and more of a recline.

Senescence as a central hallmark of aging. Telomere damage, epigenetic dysregulation, DNA damage, and mitochondrial dysfunction are primary drivers of damage in aging. Several of these drivers of damage can induce senescence. Senescence can in turn drive the consequential aging hallmarks in response to damage: stem cell exhaustion and chronic inflammation. Other responses to damage, such as proteostatic dysfunction and nutrient signaling disruption, are also integrally linked with the senescence response.

Healthy Aging

Healthy ageing is about optimizing opportunities for good health, so that older people can take an active part in society and enjoy an independent and high quality of life. In modern society is all about continuing to function emotionally, mentally, socially and physically at any age.

Ageing is not necessarily a burden, and it does not necessarily decrease a person’s ability to contribute to society: older people can make valuable and important contributions to society, and enjoy a high quality of life.

Healthy aging is not just about old age, and for many it begins much earlier; numerous studies have highlighted the benefits of looking after health from as young an age as possible, including eating a balanced diet, exercising, taking supplements for maintaining healthy bones, joints, eyes, etc. For many people, longer lives will mean an extended middle age rather than a descent into frailty, and it is important that marketers wishing to target older consumers do not lose sight of the fact that few people want to be thought of as “old”.

Life Span and Health Span

With today’s modern technologies, hospitals and doctors are able to keep people alive much longer (life span), but that doesn’t guarantee that someone’s quality of life will be good during that extended time (health span). Life span is how long we are technically alive, and health span is the length of time we are truly healthy and thriving during that time. Ideally we want our life span to equal our health span.

What can we do to increase our health span? To really ensure that our health span equals our life span, there are things we have to embrace 24/7 & 365 such as moderate exercise, tips to de-stress, eating a clean diet, and investing in anti-aging food supplements and nutrient dense super foods. Every healthy choice we make or don’t make has a direct impact on our health now, and in the future.

The optimization of health

The importance of nutrition supplementation in the ageing process:

  • To help prevent diseases
  • To provide a therapeutic effect on health
  • To delay ageing


  • Allow individuals to live a long and healthy life that will drive them to spend a good quality of life surrounded by loved ones
  • Compress the burden of disease
  • Reduce healthcare costs


A multipath Antiaging intervention strategy

Our approach is that a multipath intervention strategy targeting multiple aging pathways may promote overall health.

With the KHELMA LONGEVITY products and their unique composition, we target a critical number of well-known pathways related to health, fitness, and longevity: DNA damage, epigenetic factors, telomere erosion, mitochondrial dysfunction, proteasome function, diet or exercise induced inflammation, insulin-like growth factors, autophagy, vascular circulation, neural function, and oxidative stress.

How KHELMA LONGEVITY works at the Cellular Level

K-age™ The innovative synergistic complex

All Khelma Longevity products contain K-age™ an innovative proprietary synergistic complex obtained from Polygonum cuspidatum and Olea europea which provides biologically enhanced trans-Resveratrol.

K-age™ aims to prevent and repair cellular damage caused by free radicals, protects cells from Oxidative stress, stimulates the regeneration of cells and prevents the accumulation of damaged components in the cell by increasing proteasome levels and decreasing the levels of oxidized proteins.

Our Scientific Evidence

Anti-ageing properties of Khelma LongevityTM: treatment of human fibroblasts increases proteasome levels and decreases the levels of oxidized proteins.

In vitro pilot study indicates that Khelma Longevity™ is a potent proteasome activator demonstrating clear anti-ageing properties. The study is published in 25 September 2017 in  New Biotechnology, special issue in memory of professor Brian F.C. Clark (1936-2014) : New Biotechnology is the official journal of the European Federation of Biotechnology (EFB).

The study, determined the putative anti-ageing properties of Khelma Longevity™, a formula based on various natural compounds from the Mediterranean area. Human primary fibroblast cultures were treated with a wide range of concentrations of Khelma Longevity™ for 1 day or 3 consecutive days. Following these treatments, two major and complementary biomarkers of ageing were measured, namely, the proteasome and the amount of oxidized proteins. It was observed that 24 h of treatment with Khelma Longevity™ resulted in a maximum increase of about 41% of the total protein levels of 20S proteasome. Levels of oxidized proteins were reduced by almost 6.5-fold following longer treatments. Specifically we have observed a maximum decrease of protein carbonyls to 84.7% in comparison with nontreated control cells following 3 days of continuous treatment with Khelma Longevity™. These results support the notion that formulas rich in natural compounds from the Mediterranean area possess anti-ageing properties.